The infant aphakia treatment study iats is a multicenter randomized clinical trial comparing intraocular lens and contact lens correction for monocular aphakia. Purpose to identify patient baseline characteristics that predict recognition acuity at 4. The infant aphakia treatment study iats is a clinical study designed to determine which treatment for aphakia is better for infants between the ages of 4 weeks to 7 months who were born with a cataract in one eye. References and suggested readings plager da, lynn mj, buckley eg, et al. With publication of its 5year results, the infant aphakia treatment study iats helped illuminate the way forward for these children. Infant definition of infant by the free dictionary. The study only looked at visual acuity letters jamaophthalmology december2014 volume2,number12 1491 downloaded from. The infant aphakia treatment study iats is a multicenter randomized clinical trial. Pdf the infant aphakia treatment study design and clinical. Lessons learned about cataract surgery from the infant aphakia. Comparison of contact lens and intraocular lens correction of monocular aphakia during infancy. Hospitalsforsick children,greatormond street,london wc1n3jh. Spectacle adherence among fouryearold children in the.
Refractive shift in pseudophakic eyes during the second decade of life. Pediatric aphakia and where to place an intraocular lens. Sep 29, 2018 the infant aphakia treatment study iats compared the treatment of unilateral cataract in infants aged 16 months with primary intraocular lens iol implantation vs aphakia with contact lens cl correction. The infant aphakia treatment study contact lens experience, which compared contact lens correction for unilateral aphakia with iol implantation for children between one and six months of age, showed visual acuity outcomes were similar at age one and four and a half. Key iats recommendations here are the main messages the investigators now try to drive home, said m. Jul 29, 2016 infant aphakia treatment study g, lambert sr, lynn mj, hartmann ee, dubois l, drewsbotsch c, et al. The chop principal investigator for this study, william anninger, md, is actively enrolling patients for the trial. The infant aphakia treatment study contact lens experience t. The objective of the study is to compare iol implantation at the time of cataract extraction with the more usual treatment involving cataract extraction and correction of the resultant aphakia with a cl in infants with a unilateral congenital cataract removed between 28 days and 7 months of age. Pdf we describe our experience correcting a cohort of infants with contact lenses in the infant aphakia treatment study.
The lens of your eye is a clear, flexible structure that allows your eye to focus. Infant aphakia treatment study hhs public access am j. The optimal optical treatment of aphakia in infants is unknown. The treatments being studied are use of a contact lens cl after surgery or surgically placing a plastic lens intraocular lens. Axial elongation following cataract surgery during the first year of life in the infant aphakia treatment study. However, the infant aphakia treatment study was designed to provide empirical evidence of whether optical treatment with an iol or a contact lens after unilateral cataract surgery during. The primary objective is to compare visual acuity in children with a ucc if an intraocular lens iol is implanted at the time of cataract extraction with visual acuity in children left aphakic. The suggestion by mataftsi and colleagues that iolunder2,1 one of the largest prospective inception cohorts of congenital cataract, is insufficiently powered to report on glaucoma in unilateral cataract is challenged by striking similarities to the infant aphakia treatment study iats, a randomised controlled trial. Oct 19, 2017 aphakia is a condition that involves not having an eye lens. Pdf parenting stress in the infant aphakia treatment study. Sep 21, 2005 infant aphakia treatment study iats iats the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Study design the main inclusion criteria were a visually significant congenitalcataract 3mmcentralopacityin1eyeandanagerange of 28 days to less than 210 days at the time of cataract surgery. Strabismus surgery outcomes in the infant aphakia treatment.
In years 25 following surgery, the patients were examined by an infant aphakia treatment study certified investigator every 3 months until 4. Infant aphakia treatment study iats iats the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Iats was designed to provide empirical evidence whether optical treatment with an iol or a contact lens following unilateral cataract surgery during infancy is. To assess motor functioning in children aged 4 years 6 months enrolled in the infant aphakia treatment study, and to determine contributions of visual acuity and stereopsis to measured motor skills. Eugenie hartmann and carolyn drewsbotsch, behaviors of children with unilateral vision impairment in the infant aphakia treatment study, journal of american association for pediatric ophthalmology and strabismus, 20, 4, 320, 2016. The infant aphakia treatment study iats is a randomized, multicenter n 12 clinical trial comparing treatment of aphakia with a primary iol or contact lens in 114 infants with unilateral. Baseline characteristics of the infant aphakia treatment study. It is for this reason that the infant aphakia treatment study iats study was conceived. Patients with a unilateral cataract due to persistent fetal vasculature pfv were allowed in our study as long as the pfv. The infant aphakia treatment study iats is a multicenter, randomized, controlled clinical trial comparing iol versus contact lens treatment after cataract surgery performed in children with a unilateral congenital cataract between 1 and 6 months of age.
Fiftyseven of the 114 infants in the iats were randomized to contact lens wear. Pdf to compare the use of contact lenses and intraocular lenses iols for the optical correction of unilateral aphakia during infancy. Complications in the first 5 years following cataract surgery in infants with and without intraocular lens implantation in the infant aphakia treatment study. To determine whether infants with a unilateral congenital cataract are more likely to develop better vision following cataract extraction surgery if 1. The treatments being studied are use of a contact lens cl after surgery or surgically. Purpose to report strabismus surgery frequency and outcomes after monocular infantile cataract surgery with or without iol implantation. Parenting stress in the infant aphakia treatment study marianne celano, phd, abpp, 1 eugenie e. Factors associated with stereopsis and a good visual.
Migration to aphakia and contact lens treatment is the trend. However, the infant aphakia treatment study was designed to provide empirical evidence of whether optical treatment with an iol or a contact lens after unilateral cataract surgery during infancy is associated with a better visual outcome. Intraocular lens implantation in children with cataract the. Methods the infant aphakia treatment study iats is a randomized, multicenter clinical trial comparing treatment of aphakia with a primary iol or contact lens in 114 infants with a unilateral congenital cataract. This book aims to assist ophthalmologists in providing the best possible care for children with congenital. Infant aphakia treatment study iats full text view.
Glaucomarelated adverse events in the infant aphakia. To determine whether infants with a unilateral congenital cataract are more likely to develop. The infant aphakia treatment study is a randomized clinical trial in which the investigators compared intraocular lens iol versus contact lens correction in 114 infants, aged 28 days to infant aphakia treatment study iats is a multicenter, randomized, controlled clinical trial comparing iol versus contact lens treatment after cataract surgery performed in children with a unilateral congenital cataract between 1 and 6 months of age. The infant aphakia treatment study iats is a randomized, multicenter trial comparing visual outcomes and adverse events after the treatment of aphakia caused by unilateral congenital cataract extraction with primary intraocular lens iol implantation versus contact lens cl.
To evaluate spectacle adherence with impactresistant lenses among 4yearold children after unilateral cataract surgery in the infant aphakia treatment study. T1 glaucomarelated adverse events in the infant aphakia treatment study. This study aims to assess the current trends in the treatment of unilateral congenital cataract in infants less than 6 months at surgery in the uk and ireland. Why is there an infant aphakia treatment study iats. A concise guide to diagnosis and management pdf author ian christopher lloyd isbn 3319278460 file size 10. We describe our experience correcting a cohort of infants with contact lenses in the infant aphakia treatment study. There were 114 children enrolled in the study with 57 randomized to each treatment group. Moreover, the infant aphakia treatment study iats found that if only one half of the patients in the contact lens aphakic group eventually undergo secondary intraocular lens implantation, the number of additional intraocular surgeries in the 2 groups will be approximately equal. Parenting stress in the infant aphakia treatment study. Pdf complications in the first 5 years following cataract.
The infant aphakia treatment study contact lens experience. To describe our experience treating a cohort of unilateral aphakic infants with contact lenses in the infant aphakia treatment study iats. Motor skills of children with unilateral visual impairment in. The infant aphakia treatment study is a randomized clinical trial in which the investigators compared intraocular lens iol versus contact lens correction in 114 infants, aged 28 days to infant aphakia treatment study iats is a multicenter, randomized, controlled clinical trial of treatment for ucc. Fiftyseven infants 16 months of age were randomized to contact lens wear.
The infant aphakia treatment study iats is a randomized, controlled multicenter clinical trial with the following objectives. Design retrospective cohort analysis of randomized clinical trial data. An examination under anesthesia was performed at the time of enrollment and at approximately 1 year of age. Conclusions the optimal optical treatment of aphakia in infants is unknown. The infant aphakia treatment study iats did not find a significant difference in visual acuity for infants with a unilateral congenital cataract jun 17, 2016 fiveyear prospective data on children enrolled in the infant aphakia treatment study iats provided an opportunity to explore ocular and systemic associations in patients with a unilateral. Study protocol and statistical analysis plan pdf april 29, 2015. Jun 17, 2015 the primary aim of this study was to assess motor functioning using the mabc.
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